Maternal sucralose exposure induces Paneth cell defects and exacerbates gut dysbiosis of progeny mice
Xin Dai, Chen Wang, Zixuan Guo, Yun Li, Tianyu Liu, Ge Jin, Sinan Wang, Bangmao Wang, Kui Jiang, Hailong Cao
Abstract
, were decreased. This dysbiosis continued into adulthood. These findings showed that MS exposure induced Paneth cell defects and exacerbated gut dysbiosis in offspring mice. Sucralose should be consumed with caution, especially during pregnancy and in early life.
Topics & Concepts
SucraloseDysbiosisBiologyPaneth cellCell biologyImmunologyMicrobiologyGut floraGeneticsFood scienceEndocrinologySmall intestinePediatric health and respiratory diseasesInfant Health and DevelopmentGut microbiota and health