Highly specific and label-free histological identification of microcrystals in fresh human gout tissues with stimulated Raman scattering
Bohan Zhang, Hanlin Xu, Jun Chen, Xiaoxia Zhu, Yu Xue, Yifan Yang, Jianpeng Ao, Yinghui Hua, Minbiao Ji
Abstract
Our work demonstrated the potential of SRS microscopy for rapid intraoperative diagnosis of gout and may facilitate future fundamental researches of MSU-based diseases.
Topics & Concepts
GoutPseudogoutHistopathologyPathologyMedicineImmunohistochemistryPathophysiologySynovial fluidStainingTophusOsteoarthritisHyperuricemiaInternal medicineUric acidAlternative medicineSpectroscopy Techniques in Biomedical and Chemical ResearchGout, Hyperuricemia, Uric AcidBee Products Chemical Analysis