S-Nitrosylation-mediated dysfunction of TCA cycle enzymes in synucleinopathy studied in postmortem human brains and hiPSC-derived neurons
Paschalis‐Thomas Doulias, Hongmei Yang, Alexander Y. Andreyev, Nima Dolatabadi, Henry Scott, Charlene K Raspur, Parth Patel, Tomohiro Nakamura, Steven R. Tannenbaum, Harry Ischiropoulos, Stuart A. Lipton
Topics & Concepts
Citric acid cycleNeurodegenerationBiologyS-NitrosylationSynucleinopathiesMitochondrionEnzymeCell biologyBiochemistryOxidative phosphorylationHuman brainParkinson's diseaseNeuroscienceAlpha-synucleinDiseaseCysteineInternal medicineMedicineParkinson's Disease Mechanisms and TreatmentsMitochondrial Function and PathologyNuclear Receptors and Signaling