An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products
Marta de los Reyes Jiménez, Antonie Lechner, Francesca Alessandrini, Sina Bohnacker, Sonja Schindela, Aurélien Trompette, Pascal Haimerl, Dominique Thomas, Fiona Henkel, André Mourão, Arie Geerlof, Clarissa Prazeres da Costa, Adam Chaker, Bernhard Brüne, Rolf M. Nüsing, Per‐Johan Jakobsson, Wolfgang Andreas Nockher, Matthias J. Feige, Martin Haslbeck, Caspar Ohnmacht, Benjamin J. Marsland, David Voehringer, Nicola Harris, Carsten B. Schmidt‐Weber, Julia Esser‐von Bieren
Abstract
GDH to the airways abrogated allergic airway inflammation in mice. Thus, a metabolic enzyme present in helminth larvae can suppress type-2 inflammation by inducing an anti-inflammatory eicosanoid switch, which has important implications for the therapy of allergy and asthma.
Topics & Concepts
InflammationEicosanoidMediatorLarvaImmunologyBiologyCell biologyEnzymeEcologyBiochemistryArachidonic acidParasites and Host InteractionsNeuroendocrine regulation and behavior