Drug‑resistant <i>Acinetobacter baumannii</i>: From molecular mechanisms to potential therapeutics (Review)
Hao-Jia Wu, Zhi-Gang Xiao, Xiaojuan Lv, Hai-Tang Huang, Chu Liao, Chen-Yang Hui, Yue Xu, Heng-Fei Li
Abstract
Bacterial drug resistance is increasingly becoming an important problem that needs to be solved urgently in modern clinical practices. Infection caused by <em>Acinetobacter baumannii</em> is a serious threat to the life and health of patients. The drug resistance rate of <em>Acinetobacter baumannii</em> strains is increasing, thus research on the drug resistance of <em>Acinetobacter baumannii</em> has also seen an increase. When patients are infected with drug‑resistant<em> Acinetobacter baumannii</em>, the availability of suitable antibiotics commonly used in clinical practices is becoming increasingly limited and the prognosis of patients is worsening. Studying the molecular mechanism of the drug resistance of <em>Acinetobacter baumannii</em> is fundamental to solving the problem of drug‑resistant <em>Acinetobacter baumannii</em> and potentially other ‘super bacteria’. Drug resistance mechanisms primarily include enzymes, membrane proteins, efflux pumps and beneficial mutations. Research on the underlying mechanisms provides a theoretical basis for the use and development of antibiotics and the development of novel treatment methods.