Optogenetic control of small GTPases reveals RhoA mediates intracellular calcium signaling
Hironori Inaba, Qianqian Miao, Takao Nakata
Abstract
release from the endoplasmic reticulum (ER). The RhoA-PLCε axis induced calcium-dependent nuclear factor of activated T cells nuclear translocation, suggesting that it does activate intracellular calcium signaling. Conversely, in MDCK and HEK293T cells, RhoA-ROCK-myosin II axis induced the calcium transients. These data suggest universal coordination of RhoA and calcium signaling in cellular processes, such as cellular contraction and gene expression.
Topics & Concepts
OptogeneticsRHOAGTPaseCell biologyIntracellularCalcium signalingCalcium in biologySmall GTPaseChemistrySignal transductionNeuroscienceBiologyPhotoreceptor and optogenetics researchRetinal Development and DisordersCellular transport and secretion