Palhinosides A–H: Flavone Glucosidic Truxinate Esters with Neuroprotective Activities from <i>Palhinhaea cernua</i>
Jing Li, Lei-Hong Tan, Hui Zou, Zhen‐Xing Zou, Hongping Long, Wen‐Xuan Wang, Ping‐Sheng Xu, Lifei Liu, Kang Xu, Gui‐Shan Tan
Abstract
Palhinosides A–H (1–8), new flavone glucosidic truxinate esters, including β-truxinate and μ-truxinate forms, were isolated from Palhinhaea cernua. Their structures were elucidated by extensive spectroscopic methods and chemical analyses. The flavone glucoside cyclodimers possess a unique cyclobutane ring in their carbon scaffolds. Compounds 2–7 represent three pairs of stereoisomers (2/3, 4/5, 6/7). The protective effects of 1–8 against the damage of HT-22 cells induced by l-glutamate were evaluated, and compounds 4 and 5 showed better neuroprotective effects than the positive control, Trolox.
Topics & Concepts
CyclobutaneNeuroprotectionTroloxStereochemistryChemistryAntioxidantBiologyOrganic chemistryRing (chemistry)PharmacologyDPPHNatural product bioactivities and synthesisPhytochemistry and Biological ActivitiesMedicinal Plants and Neuroprotection