<i>In vitro</i> and <i>in vivo</i> biocompatibility and inflammation response of methacrylated and maleated hyaluronic acid for wound healing
Lijun Zhang, Ugo D’Amora, Alfredo Ronca, Yuanyuan Li, Xiaoying Mo, Fei Zhou, Mingzhou Yuan, Luigi Ambrosio, Jun Wu, Maria Grazia Raucci
Abstract
study was also performed by subcutaneous implantation of the materials in BALB/c mice for up to 28 days. In these analyses, no significant chronic inflammation reaction was demonstrated in either MEHA or MAHA in the long-term implantation.
Topics & Concepts
Hyaluronic acidIn vivoWound healingBiocompatibilityIn vitroChemistryInflammationBiomedical engineeringMedicineSurgeryBiochemistryBiotechnologyImmunologyBiologyAnatomyOrganic chemistryHydrogels: synthesis, properties, applicationsProteoglycans and glycosaminoglycans researchWound Healing and Treatments