Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells
Samuele Ferrari, Aurélien Jacob, Daniela Cesana, Marianne Laugel, Stefano Beretta, Angelica Varesi, Giulia Unali, Anastasia Conti, Daniele Canarutto, Luisa Albano, Andrea Calabria, Valentina Vavassori, Carlo Cipriani, Maria Carmina Castiello, Simona Esposito, Chiara Brombin, Federica Cugnata, Oumeya Adjali, Eduard Ayuso, Ivan Merelli, Anna Villa, Raffaella Di Micco, Anna Kajaste‐Rudnitski, Eugenio Montini, Magalie Penaud‐Budloo, Luigi Naldini
Topics & Concepts
BiologyGenome editingTransduction (biophysics)Gene deliveryViral vectorStem cellHomology directed repairGenetic enhancementProgenitor cellHaematopoiesisCell biologyDNA damageDNAComputational biologyGeneticsRecombinant DNAGeneGenomeNucleotide excision repairBiochemistryVirus-based gene therapy researchCRISPR and Genetic EngineeringCytomegalovirus and herpesvirus research