Rational designing of glyco-nanovehicles to target cellular heterogeneity
Prashant Ankur Jain, Chethan D. Shanthamurthy, Preeti Chaudhary, Raghavendra Kikkeri
Abstract
-P) of HS tetrasaccharides significantly enhanced EGFR cognate growth factor binding. The conjugation of these HS ligands to multivalent fluorescent gold nanoparticles (AuNPs) enabled the specific and efficient targeting of EGFR-overexpressed cancer cells. In addition, this heparinoid-nanovehicle exhibited selective homing to NPs in cancer cells in three-dimensional (3D) coculture spheroids, thus providing a novel target for cancer therapy and diagnostics in the tumor microenvironment (TME).
Topics & Concepts
ChemistryTumor microenvironmentHeparan sulfateOligosaccharideTumor heterogeneityBiophysicsRational designCell biologyTumor cellsBiochemistryCancer researchCancerNanotechnologyBiologyCellMaterials scienceGeneticsGlycosylation and Glycoproteins ResearchProteoglycans and glycosaminoglycans researchWnt/β-catenin signaling in development and cancer