Unlocking the anticancer activity of gambogic acid: a shift towards ferroptosis via a GSH/Trx dual antioxidant system
Jinshuai Lan, Li Liu, Wenjun Zhao, Zhe Li, Ruifeng Zeng, Shiyuan Fang, Lixia Chen, Yi Shen, Hai Wei, Tong Zhang, Yue Ding
Topics & Concepts
Gambogic acidGlutathioneAntioxidantReactive oxygen speciesChemistryLipid peroxidationCell biologyBiochemistryPro-oxidantMalondialdehydeApoptosisBiologyEnzymeFerroptosis and cancer prognosisGenomics, phytochemicals, and oxidative stressEpigenetics and DNA Methylation