Design and synthesis of thiourea-based derivatives as Mycobacterium tuberculosis growth and enoyl acyl carrier protein reductase (InhA) inhibitors
Şengül Dilem Doğan, Miyase Gözde Gündüz, Hilal Doğan, Vagolu Siva Krishna, Christian Lherbet, Dharmarajan Sriram
Topics & Concepts
INHAChemistryMycobacterium tuberculosisReductaseBiochemistryProtein Data Bank (RCSB PDB)ThioureaEnzymeDocking (animal)Acyl carrier proteinStereochemistryUncompetitive inhibitorTuberculosisOrganic chemistryBiosynthesisNon-competitive inhibitionNursingPathologyMedicineSynthesis and biological activityTuberculosis Research and EpidemiologyAntimicrobial agents and applications