Design and synthesis of thiadiazolo-carboxamide bridged β-carboline-indole hybrids: DNA intercalative topo-IIα inhibition with promising antiproliferative activity
Ramya Tokala, Sravani Sana, Uppu Jaya Lakshmi, Prasanthi Sankarana, Dilep Kumar Sigalapalli, Nikhil Gadewal, Jyoti Kode, Nagula Shankaraiah
Topics & Concepts
ChemistryCytotoxicityA549 cellApoptosisIC50Cell cultureDNA fragmentationCytotoxic T cellStereochemistryIn vitroTopoisomeraseCancer cellBiochemistryProgrammed cell deathCancerBiologyGeneticsSynthesis and bioactivity of alkaloidsCancer therapeutics and mechanismsSynthesis and Biological Evaluation