Predisposition of Inflammatory Bowel Disease Is Influenced by <b><i>IL-8</i></b>, <b><i>IL-10</i></b>, and <b><i>IL-18</i></b> Polymorphisms: A Meta-Analysis
Yanzhuo Su, Haomin Zhao
Abstract
<b><i>Background:</i></b> Whether interleukin (<i>IL</i>)-8, <i>IL-10</i>, and <i>IL-18</i> polymorphisms influence predisposition of inflammatory bowel disease (IBD) remains uncertain. <b><i>Objectives:</i></b> The authors conducted a meta-analysis to explore relationships between <i>IL-8</i>, <i>IL-10</i>, or <i>IL-18</i> polymorphisms and predisposition of IBD by merging the results of eligible literatures. <b><i>Methods:</i></b> A thorough literature search in MEDLINE, Embase, Wanfang, VIP, and CNKI was conducted by the authors to identify eligible literatures, and 33 literatures were finally selected for merged analyses. <b><i>Results:</i></b> We found that genotypic frequencies of <i>IL-8</i> rs4073, <i>IL-10</i> rs1800871, <i>IL-10</i> rs1800872, and <i>IL-10</i> rs1800896 polymorphisms among cases with IBD and population-based controls differed significantly. Moreover, we found that genotypic frequencies of <i>IL-8</i> rs4073, <i>IL-10</i> rs1800871, and <i>IL-18</i> rs1946518 polymorphisms among cases with IBD and population-based controls of Asian origin differed significantly, whereas genotypic frequency of <i>IL-10</i> rs1800896 polymorphism among cases with IBD and population-based controls of Caucasian origin also differed significantly. Furthermore, genotypic frequency of <i>IL-18</i> rs187238 polymorphism among cases with Crohn’s disease (CD) and population-based controls also differed significantly. <b><i>Conclusions:</i></b> The present meta-analysis shows that <i>IL-8</i> rs4073, <i>IL-10</i> rs1800871, <i>IL-10</i> rs1800872, <i>IL-10</i> rs1800896, and <i>IL-18</i> rs1946518 polymorphisms may influence predisposition of IBD. Furthermore, <i>IL-18</i> rs187238 polymorphism may influence predisposition of CD, but not predisposition of ulcerative colitis.