Interaction of Tau construct K18 with model lipid membranes
Mehdi Azouz, Cécile Feuillie, Michel Lafleur, Michaël Molinari, Sophie Lecomte
Abstract
AFM imaging of model membranes of controlled composition in interaction with Tau construct K18 showed PIP<sub>2</sub> induced K18 fibrillization.
Topics & Concepts
NeurodegenerationChemistryMembraneBiophysicsProtein aggregationTau proteinLipid bilayerCell biologyFibrilProtein foldingBiochemistryAlzheimer's diseaseBiologyDiseaseMedicinePathologyAlzheimer's disease research and treatmentsLipid Membrane Structure and BehaviorCellular transport and secretion