Targeting a highly conserved domain in bacterial histidine kinases to generate inhibitors with broad spectrum activity
Conrad A. Fihn, Erin E. Carlson
Topics & Concepts
BiologyHistidine kinaseResponse regulatorAntibiotic resistanceVirulenceKinaseAntimicrobialHistidineComputational biologyTwo-component regulatory systemRegulatorProtein kinase domainOrganismProtein-Serine-Threonine KinasesAntibioticsMicrobiologyBacteriaGeneticsBacterial proteinProtein kinase AGeneAmino acidMutantBacteriophages and microbial interactionsAntimicrobial Peptides and ActivitiesBacterial Genetics and Biotechnology