Protective effect and mechanism of chitooligosaccharides on acetaminophen-induced liver injury
Junwei Xiang, Jin Wang, Hong-Yi Xie, Yongjian Liu, Yan Bai, Qishi Che, Hua Cao, Guidong Huang, Jiao Guo, Zhengquan Su
Abstract
-JNK/JNK, Caspase-3 and Bax and increase the expression of Nrf2, HO-1, eNOS, SOD and Bcl-XL. COST and COSM can inhibit toxic APAP metabolism, inhibit oxidative damage and the apoptosis pathway, increase activation of the liver antioxidant pathway, and ultimately ameliorate APAP-induced liver oxidative damage.
Topics & Concepts
AcetaminophenChemistryLiver injuryPharmacologyIn vivoCYP2E1AntioxidantGlutathioneAntidoteApoptosisBiochemistryIn vitroEnzymeToxicityMedicineBiologyOrganic chemistryBiotechnologyMicrosomeDrug-Induced Hepatotoxicity and ProtectionGinger and Zingiberaceae researchDrug Transport and Resistance Mechanisms