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ChAdOx1 COVID vaccines express RBD open prefusion SARS-CoV-2 spikes on the cell surface

Tao Ni, Luiza Mendonça, Yanan Zhu, Andrew Howe, Julika Radecke, Pranav M. Shah, Yuewen Sheng, Anna-Sophia Krebs, Helen M. E. Duyvesteyn, Elizabeth Allen, Teresa Lambe, Cameron Bisset, Alexandra J. Spencer, Susan Morris, David I. Stuart, Sarah C. Gilbert, Peijun Zhang

2023iScience20 citationsDOIOpen Access PDF

Abstract

structure determination as a powerful means for studying antigen design options in future vaccine development against emerging novel SARS-CoV-2 variants and broadly against other infectious viruses.

Topics & Concepts

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)VirologyCoronavirus2019-20 coronavirus outbreakBiologyMedicineInfectious disease (medical specialty)DiseaseOutbreakPathologySARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesVirus-based gene therapy research
ChAdOx1 COVID vaccines express RBD open prefusion SARS-CoV-2 spikes on the cell surface | Litcius