Lycorine, a natural alkaloid, promotes the degradation of alpha-synuclein via PKA-mediated UPS activation in transgenic Parkinson's disease models
Qi Zhu, Xu‐Xu Zhuang, Jiayue Chen, Ningning Yuan, Yan Chen, Cui-Zan Cai, Jieqiong Tan, Huanxing Su, Jiahong Lu
Topics & Concepts
LycorineProteasomeTransgeneChemistryCell biologyGenetically modified mouseDownregulation and upregulationMolecular biologyBiologyBiochemistryAlkaloidStereochemistryGeneChemical synthesis and alkaloidsPlant and fungal interactionsNeurotransmitter Receptor Influence on Behavior