Visible Light Promotes Cascade Trifluoromethylation/Cyclization, Leading to Trifluoromethylated Polycyclic Quinazolinones, Benzimidazoles and Indoles
Ransong Ma, Yuanyuan Ren, Zhoubin Deng, Ke‐Hu Wang, Junjiao Wang, Danfeng Huang, Yulai Hu, Xiaobo Lv
Abstract
Efficient visible-light-induced radical cascade trifluoromethylation/cyclization of inactivated alkenes with CF3Br, which is a nonhygroscopic, noncorrosive, cheap and industrially abundant chemical, was developed in this work, producing trifluoromethyl polycyclic quinazolinones, benzimidazoles and indoles under mild reaction conditions. The method features wide functional group compatibility and a broad substrate scope, offering a facile strategy to pharmaceutically produce valuable CF3-containing polycyclic aza-heterocycles.
Topics & Concepts
TrifluoromethylationChemistryCombinatorial chemistryTrifluoromethylCascadeCascade reactionOrganic chemistryCatalysisChromatographyAlkylFluorine in Organic ChemistryRadical Photochemical Reactions