An allosteric palindromic hairpin probe based dual-mode interactive strand displacement amplification enables robust miRNA biosensing
Qi Wang, Tong Zhou, Danni Xue, Haidong Yang, Zhuqi Sui, Xinyue Yuan, Jianguo Xu
Abstract
This study introduces an allosteric palindromic hairpin probe (APHP)-based dual-mode interactive strand displacement amplification (DMI-SDA) system for ultrasensitive detection of microRNA-155. The system achieves exceptional signal amplification and improved signal preservation using dimeric G-triplexes as signal reporters, enabling robust detection of miRNA-155, representing a promising avenue in molecular diagnosis.
Topics & Concepts
Allosteric regulationBiosensorDisplacement (psychology)PalindromeMultiple displacement amplificationBiophysicsSIGNAL (programming language)Dual (grammatical number)ChemistryDual modeBiological systemNanotechnologyMaterials scienceComputer scienceBiologyElectronic engineeringCRISPRBiochemistryReceptorPolymerase chain reactionEngineeringGeneProgramming languagePsychologyPsychotherapistDNA extractionArtLiteratureAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryDNA and Nucleic Acid Chemistry