Electrochemical 1,3‐Oxofluorination of <i>Gem</i>‐Difluoro Cyclopropanes: Approach to <i>α</i>‐CF<sub>3</sub>‐Substituted Carbonyl Compounds
Shiv Dutt, Rakesh Kumar, Nakshatra Banerjee, Debarshi Saha, Prabal Banerjee
Abstract
Abstract An electrochemical methodology for the construction of α ‐CF 3 ‐substituted carbonyl compounds in moderate to good yields under exogenous metal and oxidant‐free conditions has been developed. The protocol involves the single‐electron oxidation of the aryl ring to generate a radical cation followed by a three‐electron S N 2 reaction resulting in the formation of α ‐CF 3 substituted ketones.
Topics & Concepts
ChemistryElectrochemistryArylRing (chemistry)Medicinal chemistryOrganic chemistryElectrodePhysical chemistryAlkylFluorine in Organic ChemistryInorganic Fluorides and Related Compounds