GSH-resistant and highly cytoselective ruthenium(<scp>ii</scp>)-<i>p</i>-cymene-(imidazo[4,5-<i>f</i>][1,10]phenanthrolin-2-yl)phenol complexes as potential anticancer agents
Binoy Kar, Utpal Das, Sourav De, Sudhindra Pete, Ajay Sharma S, Nilmadhab Roy, Ashok Kumar S K, Debashis Panda, Priyankar Paira
Abstract
To avoid the side effects of the current popular platinum-based anticancer drugs, researchers have made tireless attempts to design appropriate GSH-resistant Ru(ii)-arene complexes. In this regard, luminescent ruthenium(ii)-p-cymene-imidazophenanthroline complexes were developed as promising highly cytoselective cancer theraputic agents for HeLa and Caco-2 cells.
Topics & Concepts
RutheniumHeLaChemistryp-CymeneCombinatorial chemistryStereochemistryGlutathioneMedicinal chemistryBiochemistryEnzymeIn vitroCatalysisMetal complexes synthesis and propertiesFerrocene Chemistry and ApplicationsAdvanced biosensing and bioanalysis techniques