A T cell inflammatory phenotype is associated with autoimmune toxicity of the PI3K inhibitor duvelisib in chronic lymphocytic leukemia
Deepti Gadi, Alec Griffith, Svitlana Tyekucheva, Zixu Wang, Vanessa Rai, Alexander R. Vartanov, Emily M. Thrash, Stacey M. Fernandes, Timothy Z. Lehmberg, Brandon Lee, Stephen P. Martindale, John‐Hanson Machado, Oreofe O. Odejide, Philippe Armand, David C. Fisher, Jon Arnason, Matthew S. Davids, James A. Lederer, Jennifer R. Brown
Topics & Concepts
MedicineChronic lymphocytic leukemiaChemoimmunotherapyImmunologyCD8ToxicityCytotoxic T cellFludarabineLeukemiaCyclophosphamideImmune systemInternal medicineBiologyChemotherapyBiochemistryIn vitroChronic Lymphocytic Leukemia ResearchImmunodeficiency and Autoimmune DisordersPI3K/AKT/mTOR signaling in cancer