Morpholine-modified thiosemicarbazones and thiazolidin-4-ones against Alzheimer’s key enzymes: From synthesis to inhibition
Yeliz Demir, Halil Şenol, Orhan Uluçay, Şeyma Ateşoğlu, Feyzi Sinan Tokalı
Topics & Concepts
MorpholineChemistryIn silicoADMECytotoxicityButyrylcholinesteraseStereochemistryCombinatorial chemistryCholinesteraseAmine gas treatingEnzymeTertiary amineBiochemistryAcetylcholinesteraseMolecular modelPyrrolidineActive siteLipophilicityDocking (animal)Structure–activity relationshipIn vitroBinding siteEnzyme inhibitionRational designPiperidineReactivity (psychology)Enzyme kineticsSynthesis and biological activityCholinesterase and Neurodegenerative DiseasesEnzyme function and inhibition