Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASH
Sabine Daemen, Anastasiia Gainullina, Gowri Kalugotla, He Li, Mandy M. Chan, Joseph W. Beals, Kim Liss, Samuel Klein, Ariel E. Feldstein, Brian N. Finck, Maxim N. Artyomov, Joel D. Schilling
Abstract
(Cell Reports 34, 108626; January 12, 2021) In the original published version of this paper, a declaration of interests was accidently omitted: “B.N.F. is a member of the scientific advisory board and has stock in Cirius Therapeutics, which is developing MPC inhibitors for clinical use.” This has been corrected online. The authors apologize for this error. Dynamic Shifts in the Composition of Resident and Recruited Macrophages Influence Tissue Remodeling in NASHDaemen et al.Cell ReportsJanuary 12, 2021In BriefHepatic macrophages are thought to be essential in the pathogenesis of NASH; however, the underlying mechanisms remain unclear. Daemen et al. demonstrate infiltration of distinct populations of recruited monocyte-derived macrophages in the NASH liver, which form hepatic crown-like structures and influence tissue fibrosis. Full-Text PDF Open Access