Design, synthesis and biological evaluation of indole-based [1,2,4]triazolo[4,3-a] pyridine derivatives as novel microtubule polymerization inhibitors
Chengjun Wu, Jia‐Qiang Wu, Yunfei Hu, Suyun Pu, Yuying Lin, Zimai Zeng, Jinhui Hu, Wen‐Hua Chen
Topics & Concepts
ChemistryHeLaIndole testPyridineStereochemistryTubulinSubstituentPolymerizationMicrotubuleMicrotubule polymerizationCell cycle checkpointCell cycleApoptosisCellBiochemistryOrganic chemistryPolymerCell biologyBiologyClick Chemistry and Applications14-3-3 protein interactionsSynthesis and biological activity