In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA
Lukas Villiger, Tanja Rothgangl, Dominik Witzigmann, Rurika Oka, Paulo J.C. Lin, Weihong Qi, Sharan Janjuha, Christian Berk, Femke Ringnalda, Mitchell Beattie, Markus Stoffel, Beat Thöny, Jonathan Hall, Hubert Rehrauer, Ruben van Boxtel, Ying K. Tam, Gerald Schwank
Topics & Concepts
CytidineRNARNA editingBiologyCytidine deaminaseTranscriptomeDNAGenome editingMolecular biologyBase pairGeneticsComputational biologyGenomeGeneGene expressionBiochemistryEnzymeCRISPR and Genetic EngineeringRNA regulation and diseaseRNA and protein synthesis mechanisms