Non-ionotropic voltage-gated calcium channel signaling
Michael Trus, Daphné Atlas
Abstract
. We emphasize the recognition of calcium ion occupancy within the open ion-pore and its contribution to the excitation coupling processes that precede the influx of calcium. The non-ionotropic activation of VGCCs, triggered by the upstroke of an action potential, provides a conceptual framework to elucidate the mechanistic aspects underlying the microseconds nature of synaptic transmission, cardiac contractility, and the rapid induction of first-wave genes.
Topics & Concepts
Ionotropic effectChemistryBiophysicsIon channelVoltage-dependent calcium channelT-type calcium channelDepolarizationCalcium signalingStretch-activated ion channelCalciumExtracellularIntracellularVoltage-gated ion channelCell biologyGlutamate receptorBiochemistryBiologyReceptorOrganic chemistryNeuroscience and Neuropharmacology ResearchIon channel regulation and functionNeuroscience and Neural Engineering