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Dynamics of a Fractional-Order Delayed Model of COVID-19 with Vaccination Efficacy

Fathalla A. Rihan, K. Udhayakumar, Hebatallah J. Alsakaji, Nicola Sottocornola

2023Vaccines19 citationsDOIOpen Access PDF

Abstract

In this study, we provide a fractional-order mathematical model that considers the effect of vaccination on COVID-19 spread dynamics. The model accounts for the latent period of intervention strategies by incorporating a time delay τ. A basic reproduction number, R0, is determined for the model, and prerequisites for endemic equilibrium are discussed. The model's endemic equilibrium point also exhibits local asymptotic stability (under certain conditions), and a Hopf bifurcation condition is established. Different scenarios of vaccination efficacy are simulated. As a result of the vaccination efforts, the number of deaths and those affected have decreased. COVID-19 may not be effectively controlled by vaccination alone. To control infections, several non-pharmacological interventions are necessary. Based on numerical simulations and fitting to real observations, the theoretical results are proven to be effective.

Topics & Concepts

VaccinationBasic reproduction numberEpidemic modelStability (learning theory)Hopf bifurcationCoronavirus disease 2019 (COVID-19)MathematicsPsychological interventionIntervention (counseling)Dynamics (music)Equilibrium pointApplied mathematicsOrder (exchange)MedicineBifurcationComputer scienceEconomicsVirologyPsychologyDiseasePhysicsMathematical analysisEnvironmental healthDifferential equationPopulationMachine learningNonlinear systemPathologyFinancePedagogyQuantum mechanicsPsychiatryInfectious disease (medical specialty)Fractional Differential Equations SolutionsMathematical and Theoretical Epidemiology and Ecology ModelsCOVID-19 epidemiological studies