Synthesis of hybrids thiazole–quinoline, thiazole–indole and their analogs: <i>in vitro</i> anti-proliferative effects on cancer cell lines, DNA binding properties and molecular modeling
Paulo Fernando da Silva Santos-Júnior, Igor José dos Santos Nascimento, Edjan Carlos D. da Silva, Kadja Luana Chagas Monteiro, Johnnatan Duarte de Freitas, Samaysa de Lima Lins, Thamilla Maria S. Maciel, Bruno Coêlho Cavalcanti, José de Brito Vieira Neto, Fabiane C. de Abreu, Ísis M. Figueiredo, Josué Carinhanha Caldas Santos, Cláudia Pessoa, Edeildo Ferreira da Silva‐Júnior, João Xavier de Araújo‐Júnior, Thiago Mendonça de Aquino
Abstract
A quinoline–thiazole hybrid was synthesized, which showed cytotoxicity against the HL-60 cell line. Electrochemical and spectroscopic experiments suggested DNA as the biological target.
Topics & Concepts
ChemistryThiazoleQuinolineIndole testIn vitroDNACancer cell linesStereochemistryCombinatorial chemistryCancer cellCancerBiochemistryOrganic chemistryGeneticsBiologySynthesis and biological activitySynthesis and Biological EvaluationClick Chemistry and Applications