EZH2 suppresses IR-induced ferroptosis by forming a co-repressor complex with HIF-1α to inhibit ACSL4: Targeting EZH2 enhances radiosensitivity in KDM6A-deficient esophageal squamous carcinoma
Guizhen Pan, Yeye Xia, Mengyu Hao, Jiahao Guan, Qianqian Zhu, Tianqi Zha, Lei Sheng, Zhenfeng Zhao, Huaguang Pan, Weiyang Fang, Xiaoyong Xu, Xiangcun Chen, Shuguang Zhou, Zhuting Tong
Topics & Concepts
EZH2DemethylaseCancer researchChromatin immunoprecipitationRadiosensitivityChemistryRepressorGambogic acidCell cultureMolecular biologyBiologyMethylationGeneIn vitroTranscription factorPromoterBiochemistryGene expressionMedicineEpigeneticsRadiation therapyInternal medicineGeneticsEpigenetics and DNA MethylationFerroptosis and cancer prognosisRNA modifications and cancer