FXR deletion attenuates intestinal barrier dysfunction in murine acute intestinal inflammation
MaKayla L O'Guinn, David A. Handler, Jonathan J. Hsieh, Michael U. Mallicote, Karina Feliciano, Christopher P. Gayer
2024American Journal of Physiology-Gastrointestinal and Liver Physiology10 citationsDOIOpen Access PDF
Abstract
Intestinal barrier failure is a hallmark in gut-origin sepsis. We demonstrate that the intestinal barriers of farnesoid-X receptor (FXR) knockout (KO) animals are protected from inflammatory insult using multiple models of acute intestinal inflammation. This protection is due to decreased inflammatory cytokine production and maintenance of tight junctional architecture seen within the KO animals. This is the first report of FXR deletion being protective to the intestinal barrier.
Topics & Concepts
Farnesoid X receptorOccludinInflammationBile acidInflammatory bowel diseaseProinflammatory cytokineInternal medicineTight junctionIntestinal permeabilitySepsisEndocrinologyImmunologyBiologyNuclear receptorMedicineTranscription factorCell biologyBiochemistryDiseaseGeneDrug Transport and Resistance MechanismsHelicobacter pylori-related gastroenterology studiesInflammatory Bowel Disease