Mandelic acid catalyzed one-pot three-component synthesis of α-aminonitriles and α-aminophosphonates under solvent-free conditions at room temperature
Gurpreet Kaur, Mussarat Shamim, Vaishali Bhardwaj, Vivek K. Gupta, Bubun Banerjee
Abstract
A simple, mild, straightforward, efficient and eco-friendly protocol has been developed for the synthesis of a series of α-aminonitriles via the one-pot three-component Strecker reactions between various aldehydes, amines and trimethylsilyl cyanide using a catalytic amount of mandelic acid as a naturally occurring, low-cost, efficient organo-catalyst under solvent-free conditions at room temperature. Under the same optimized conditions synthesis of α-aminophosphonates were also achieved via the one-pot three-component Kabachnik-Fields reactions of aldehydes, amines and triethyl phosphate.
Topics & Concepts
ChemistryTrimethylsilyl cyanideCatalysisStrecker amino acid synthesisMandelic acidSolid acidOne-pot synthesisOrganic chemistrySolventComponent (thermodynamics)Combinatorial chemistryPhysicsThermodynamicsEnantioselective synthesisOrganophosphorus compounds synthesisSulfur-Based Synthesis TechniquesChemical Synthesis and Reactions