Uptake of Cascade Genetic Testing for Hereditary Breast and Ovarian Cancer: A Systematic Review and Meta-Analysis
Muhammad Danyal Ahsan, Isabelle Chandler, Samantha Min, Benjamin Grant, Michelle Primiano, Jamieson H. Greenwald, Tamar Nicole Soussana, Becky Baltich Nelson, Charlene Thomas, Eloise Chapman‐Davis, Ravi Sharaf, Melissa K. Frey
Abstract
This is a systematic review and meta-analysis evaluating the uptake of cascade genetic testing for hereditary breast and ovarian cancer syndrome. Among 30 studies included for meta-analysis, the uptake of cascade genetic testing was 33% (95% CI 25%-42%), with higher uptake rates among females compared with male relatives, and among first-degree compared with second-degree relatives. These findings indicate suboptimal uptake of cascade genetic testing among people at risk for hereditary breast and ovarian cancer syndrome, representing a missed opportunity for cancer prevention and early detection. There is a need for interventions to improve uptake rates.