Phloretin decreases microglia-mediated synaptic engulfment to prevent chronic mild stress-induced depression-like behaviors in the mPFC
Chenchen Li, Bo Liu, Jingyi Xu, Bin Jing, Lijie Guo, Liyong Wang, Milin Wang, Haochen Zhang, Qianqian He, Xin Yu, Yan Zhang, Qing Xu, Yutao Yang
Abstract
Our results indicate that PHL represses the NF-κB-C3 axis and subsequent microglia-mediated synaptic engulfment to protect against CMS-induced depression in the mPFC.
Topics & Concepts
MicrogliaPrefrontal cortexNeuroprotectionChemistrySynapseDendritic spineNeurosciencePhloretinOxidative stressCell biologyMedicineInternal medicineBiologyInflammationBiochemistryHippocampal formationCognitionNeuroinflammation and Neurodegeneration MechanismsTryptophan and brain disordersStress Responses and Cortisol