Permissive Conformations of a Transmembrane Helix Allow Intramembrane Proteolysis by γ-Secretase
Martin Ortner, Nadja Guschtschin-Schmidt, Walter Stelzer, Claudia Muhle‐Goll, Dieter Langosch
Topics & Concepts
Transmembrane domainProteolysisTransmembrane proteinBiochemistryHelix (gastropod)MutagenesisProtein structureProteaseProtein subunitBiologyChemistryBiophysicsStereochemistryEnzymeMutantAmino acidReceptorGeneSnailEcologyCellular transport and secretionChemical Synthesis and AnalysisProtein Kinase Regulation and GTPase Signaling