Rhoifolin loaded in PLGA nanoparticles alleviates oxidative stress and inflammation <i>in vitro</i> and <i>in vivo</i>
Eveen Al‐Shalabi, Samah Abusulieh, Alaa M. Hammad, Suhair Sunoqrot
Abstract
anti-inflammatory activity was evaluated in a formalin-induced rat paw edema model. The results showed that ROF NPs were superior to free ROF in mitigating the histopathological changes in the inflamed paw tissues. Moreover, the NPs were equally potent to free ROF and the nonsteroidal anti-inflammatory drug diclofenac in terms of inhibiting the increase in paw thickness, normalizing nitric oxide levels, and modulating the gene expression of pro-inflammatory cytokines in the inflamed paw tissues. Our findings present a promising nanocarrier platform that can enhance the solubility and control the release of ROF, which will facilitate its administration in the treatment of inflammatory diseases.