Proximal tubule cyclophilin D mediates kidney fibrogenesis in obstructive nephropathy
Hee‐Seong Jang, Mi Ra Noh, Ligyeom Ha, Jinu Kim, Babu J. Padanilam
Abstract
It has been established that renal proximal tubule (PT) injury is a primary cause of the development of chronic kidney disease, but the underlying molecular mechanism remains to be defined. Here, we show that cyclophilin D, a mitochondrial matrix protein, in the PT causes kidney fibrogenesis in obstructive nephropathy. Our data suggest that targeting PT cyclophilin D could be beneficial to prevent fibrosis progression.
Topics & Concepts
KidneyFibrosisAcute kidney injuryKidney diseaseMedicineMyofibroblastPathologyInternal medicineEndocrinologyAcute Kidney Injury ResearchChronic Kidney Disease and DiabetesDialysis and Renal Disease Management