Quantitative Perfusion Imaging with Total-Body PET
Juhani Knuuti, Jouni Tuisku, Henri Kärpijoki, Hidehiro Iida, Teemu Maaniitty, Aino Latva‐Rasku, Vesa Oikonen, Sergey V. Nesterov, Jarmo Teuho, Maria K. Jaakkola, Riku Klén, Heli Louhi, Virva Saunavaara, Pirjo Nuutila, Antti Saraste, Juha O. Rinne, Lauri Nummenmaa
Abstract
Recently, PET systems with a long axial field of view have become the current state of the art. Total-body PET scanners enable unique possibilities for scientific research and clinical diagnostics, but this new technology also raises numerous challenges. A key advantage of total-body imaging is that having all the organs in the field of view allows studying biologic interaction of all organs simultaneously. One of the new, promising imaging techniques is total-body quantitative perfusion imaging. Currently, <sup>15</sup>O-labeled water provides a feasible option for quantitation of tissue perfusion at the total-body level. This review summarizes the status of the methodology and the analysis and provides examples of preliminary findings on applications of quantitative parametric perfusion images for research and clinical work. We also describe the opportunities and challenges arising from moving from single-organ studies to modeling of a multisystem approach with total-body PET, and we discuss future directions for total-body imaging.