Novel Lignin-Capped Silver Nanoparticles against Multidrug-Resistant Bacteria
Yael N. Slavin, Kristina Ivanova, Javier Hoyo, Ilana Perelshtein, Gethin Owen, Anne Haegert, Yen‐Yi Lin, Stéphane LeBihan, Aharon Gedanken, Urs O. Häfeli, Tzanko Tzanov, Horacio Bach
Abstract
genes linked with efflux, heavy metal resistance, capsular biosynthesis, and quorum sensing were investigated for changes in gene expression upon sublethal exposure to the silver-lignin NPs. Genes encoding for membrane proteins with an efflux function were upregulated. However, all other genes were membrane proteins that did not efflux metals and were downregulated.
Topics & Concepts
Quorum sensingPseudomonas aeruginosaMicrobiologyAcinetobacter baumanniiEffluxBacteriaAntimicrobialMultiple drug resistanceStaphylococcus epidermidisLigninAntibioticsStaphylococcus aureusAntibiotic resistanceBiologyBiochemistryBiofilmGeneticsBotanyNanoparticles: synthesis and applicationsPharmaceutical and Antibiotic Environmental ImpactsPhenothiazines and Benzothiazines Synthesis and Activities