Systemic inflammation-induced adipose tissue remodeling drives psoriasis exacerbation in obesity through epigenetic and immunometabolic dysregulation
Jinsun Jang, Mi Sun Ahn, Jiyeong Jeong, Eun Hui Lee, Ok‐Hee Kim, Seul-A Joo, Seung Eun Baek, Han‐Joo Maeng, Yun Hak Kim, In‐Sun Hong, Byung‐Chul Oh, Ik Soo Kim, Hee Joo Kim, YunJae Jung
Abstract
These findings suggest that obesity sensitizes adipose tissue to homeostatic disruption, establishing it as a critical immunometabolic interface that drives psoriasis exacerbation in response to systemic inflammatory cues.
Topics & Concepts
InflammationAdipose tissuePsoriasisExacerbationEpigeneticsObesitySystemic inflammationMedicineInternal medicineBiologyImmunologyGeneBiochemistryPsoriasis: Treatment and PathogenesisIL-33, ST2, and ILC PathwaysDermatology and Skin Diseases