Electrochemical 1,3-Alkyloxylimidation of Arylcyclopropane Radical Cations: Four-Component Access to Imide Derivatives
Wei Zhou, Peng Chen, Zi-Qiong Li, Li-Tong Xiao, Jiang Bai, Xian‐Rong Song, Mu‐Jia Luo, Qiang Xiao
Abstract
Herein, a general electrochemical radical-cation-mediated four-component ring-opening 1,3-alkyloxylimidation of arylcyclopropanes, acetonitrile, carboxylic acids, and alcohols is described, providing a facile and sustainable approach to quickly construct structurally diverse imide derivatives from easily available raw materials in an operationally simple undivided cell. This metal-catalyst- and oxidant-free single-electron oxidation strategy offers a green alternative for the formation of highly reactive cyclopropane-derived radical cations, and this protocol features a broad functional group tolerance.
Topics & Concepts
ChemistryImideAcetonitrileElectrochemistryCyclopropaneCatalysisRing (chemistry)Functional groupCombinatorial chemistryComponent (thermodynamics)Organic chemistryElectrodePhysicsPhysical chemistryThermodynamicsPolymerRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms