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Microautophagy: definition, classification, and the complexity of the underlying mechanisms

Yasuyoshi Sakai, Christian Behrends, Ana María Cuervo, Jayanta Debnath, Masanori Izumi, Andreas Jenny, Maurizio Molinari, Shuhei Nakamura, Masahide Oku, Marisa S. Otegui, Laura Santambrogio, Han‐Ming Shen, Tomohiko Taguchi, Michael Thumm, Takashi Ushimaru, Zhiping Xie, Fulvio Reggiori

2025Autophagy8 citationsDOIOpen Access PDF

Abstract

ATG, autophagy related; e-MI, endosomal microautophagy; ER, endoplasmic reticulum; ESCRT, endosomal sorting complex required for transport; EV, extracellular vesicle; HSPA8/HSC70, heat shock protein family A (Hsp70) member 8; ILVs, intralumenal vesicles; l-MI, lysosomal microautophagy; MAP1LC3/LC3, microtubule associated protein 1 light chain 3; MCOLN1, mucolipin TRP cation channel 1; microautophagy, MI-autophagy; MVBs, multivesicular bodies; SQSTM1, sequestosome 1; v-MI, vacuolar microautophagy.

Topics & Concepts

BiologyEndosomeCell biologyEndoplasmic reticulumSequestosome 1AutophagyProteostasisIntracellularConfusionExtracellularEndocytosisMicrotubuleHeat shock proteinTransport proteinSorting nexinRetromerBiogenesisBAG3LysosomeCompartment (ship)Protein targetingLipid-anchored proteinBiochemistryoskarLipid microdomainSortingTetrahymenaAutophagy in Disease and TherapyExtracellular vesicles in diseaseMicroRNA in disease regulation
Microautophagy: definition, classification, and the complexity of the underlying mechanisms | Litcius