PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis
Xinxin Song, Jiao Liu, Feimei Kuang, Xin Chen, Herbert J. Zeh, Rui Kang, Guido Kroemer, Yangchun Xie, Daolin Tang
Abstract
inhibitors in vitro and in suitable preclinical mouse models (e.g., a high-fat diet diabetes model). These findings reveal metabolic reprogramming as a potential target for overcoming ferroptosis resistance.
Topics & Concepts
PDK4ChemistryBeta oxidationPyruvate dehydrogenase complexBiochemistryGlycolysisResistance (ecology)Fatty acidCell biologyMetabolismBiologyEnzymeEcologyFerroptosis and cancer prognosisRNA modifications and cancerCancer, Lipids, and Metabolism