Palladium‐Catalyzed Stereoselective Intramolecular Heck Dearomative Silylation of Indoles
Gang Wang, Mingzhu Wei, Tianxiang Liu, Weiwei Jin, Yonghong Zhang, Bin Wang, Yu Xia, Chenjiang Liu
Abstract
Abstract A palladium‐catalyzed stereoselective intramolecular Heck dearomative of indoles with silyl termination has been developed. A type of tetracyclic indoline derivatives containing silicon were prepared, involving N ‐(2‐bromobenzoyl)indoles and silylboronates. This protocol not only led to a broad substrate scope in acceptable yields but also could be scaled up to gram quantities as well as further synthetic transformation. magnified image
Topics & Concepts
ChemistryIntramolecular forceStereoselectivityPalladiumSilylationIndolineCatalysisHeck reactionSubstrate (aquarium)Palladium catalystCombinatorial chemistryOrganic chemistryGeologyOceanographyCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsRadical Photochemical Reactions