Host–guest binding of tetracationic cyclophanes to photodynamic agents inhibits posttreatment phototoxicity and maintains antitumour efficacy
Jianda Sun, Yamin Liu, Zijian Zhao, Shang‐Bo Yu, Qiao‐Yan Qi, Wei Zhou, Hui Wang, Ke Hu, Dan‐Wei Zhang, Zhan‐Ting Li
Abstract
quantum yield. We show that one of the cyclophanes, 2,6-NpBox, could include the PDAs to efficiently suppress their photosensitivity for the generation of reactive oxygen species. A tumour-bearing mouse model study revealed that, when Photofrin, the most widely used PDA in clinic, was administrated at a dose corresponding to the clinical one, 2,6-NpBox of the same dose could significantly suppress its posttreatment phototoxicity on the skin induced by simulated sunlight irradiation, without imposing a negative influence on its PDT efficacy.
Topics & Concepts
PhototoxicityPhotodynamic therapyPharmacologyMedicineChemistryBiochemistryIn vitroOrganic chemistryPhotodynamic Therapy Research StudiesPorphyrin and Phthalocyanine ChemistryNanoplatforms for cancer theranostics