Sandmeyer-Type Reductive Disulfuration of Anilines
Shiqi Chen, Si Cao, Chaoyang Liu, Baoxu Wang, Xiaorui Ren, Hang Huang, Zhihong Peng, Xi Wang
Abstract
A transition metal/ligand-free disulfuration of anilines with disulfur transfer reagents (dithiosulfonate or tetrasulfide) is reported herein. The reaction, which can be considered as a reductive disulfuration variation of the classic Sandmeyer reaction, is performed under mild conditions and exhibits broad scope across the aniline substrate and disulfur transfer reagent classes. The gram-scale synthesis of disulfides is successfully achieved through this method, rendering the approach highly valuable.
Topics & Concepts
ReagentChemistryAnilineCombinatorial chemistrySubstrate (aquarium)Ligand (biochemistry)Organic chemistryReceptorOceanographyBiochemistryGeologySulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsCatalytic C–H Functionalization Methods