Synthesis, characterization and anti-breast cancer potential of an incensole acetate nanoemulsion from <i>Catharanthus roseus</i> essential oil; <i>in silico</i> , <i>in vitro</i> , and <i>in vivo</i> study
Iffat Nayila, Sumaira Sharif, Madeeha Shahzad Lodhi, Muhammad Fayyaz ur Rehman, Farhana Aman
Abstract
activity of IA against breast cancer targets was observed by molecular docking, ADMET assessment and molecular dynamics simulations. The IA-mediated nanoformulation exhibited cytotoxicity against breast cancer cell lines at an effective concentration when analyzed by MTT and crystal violet assay. The increased interleukin serum indicators were significantly improved as a result of nanoemulsion treatment in a DMBA-induced rat model. In addition, the anticancer properties of IA biosynthesized nanoemulsion are supported due to their potential effects on biochemical parameters, oxidative stress markers, proinflammatory cytokines, and upon tumor growth profiling in cancer-induced rats.