Dual functional quaternary chitosans with thermoresponsive behavior: structure–activity relationships in antibacterial activity and biocompatibility
Sedigheh Borandeh, Isabella Laurén, Arun Kumar Teotia, Jukka Niskanen, Jukka Seppälä
Abstract
. Furthermore, we detected concentration-dependent cytotoxicity in NIH-3T3 fibroblasts. Striking a balance between antimicrobial activity and cytotoxicity becomes a crucial factor in application feasibility. AETMAC-functionalized chitosan emerges as the top performer in terms of overall antibacterial effectiveness, possibly owing to factors like molecular weight, charge characteristics, and variations in the quaternary linker. Quaternary chitosan derivatives, with their excellent antibacterial attributes, hold significant promise as antibacterial or sanitizing agents, as well as across a broad spectrum of biomedical and environmental contexts.
Topics & Concepts
BiocompatibilityChitosanMaterials scienceAntimicrobialAntibacterial activityBroad spectrumDual (grammatical number)NanotechnologyCombinatorial chemistryChemical engineeringChemistryBacteriaOrganic chemistryBiologyEngineeringLiteratureArtMetallurgyGeneticsNanocomposite Films for Food PackagingAntimicrobial agents and applicationsAdvanced Drug Delivery Systems